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Two are known: The Utopians, who focus on a harmonic union between civilization and nature, where evolution is a slow, guided process and the Adaptationists, who believe that the guilds exist in a fragile ecosystem in which the slightest imbalance can have cascading effects, and thus seek to take steps that will ensure their survival. Independently from the Clades operate factions about the interpretation of Simic philosophy. Gyre Clade, focusing on redirecting or nullifying magic and advancing nature.Crypsis Clade, focusing on camouflage and magic designed to hide knowledge or operations.

Fin Clade, focusing on the movement of creatures (especially flying creatures) as well as, movement of resources through systems.Hull Clade, focusing on protection, defense, and durability.A Clade is a group that's focused on a specific aspect of the Combine or project.

Where other cultures are divided by species, caste or role, within the Simic Combine, members are divided by Clade. Even so, the Simic makes up the physicians of Ravnica and so injuries and illness are taken to reputable doctors. The emotionally distant relationship that the Simic biomancers have with the rest of Ravnica's society makes the common man wary of the guild, thinking of them as crazy mutant makers. A few multiply and become part of the guild's fabric.

Some of these are unique creatures that can't reproduce. The guild uses magic to coax new morphologies from existing creatures, as well as to combine traits from multiple organisms in one. The guild seeks to protect the elements of the plane that are incompatible or mutually exclusive with its overpopulated, urban conditions. The Simic Combine is Ravnica's steward of nature and the wild its mission is to preserve the natural world even as Ravnica's cities continue to grow.

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